The Taoiseach, Tánaiste and ministers will head to America, Africa and Australia as 86 cities in 48 countries are visited during St Patrick's week.
The list of destinations was agreed by Cabinet on Tuesday and will see Taoiseach Leo Varadkar heading to Washington DC for the traditional shamrock ceremony at the White House with US President Joe Biden.
He will also visit the city of Boston, while Tánaiste Micheál Martin goes to Vancouver, Ottawa and Toronto.
A total of 38 state representatives will travel across the globe.
Environment Minister Eamon Ryan will travel to Brazil, Finance Minister McGrath will go to China, Public Expenditure Minister Paschal Donohoe will visit France and Bulgaria and Enterprise Minister Simon Coveney will travel to India and Bangladesh.
Education Minister Norma Foley will visit Cardiff, Edinburgh, Manchester and London, while Media Minister Catherine Martin will visit Nashville and Austin.
Housing Minister Darragh O'Brien will travel to South Africa and Zambia, with Agriculture Minister Charlie McConalogue will go to Kenya, Ethiopia and South Sudan, with Social Protection Minister Heather Humphreys going to Chicago and Madison in the US.
Justice Minister Helen McEntee will head to New York for five days, while Health Minister Stephen Donnelly will be sent to Australia.
A statement from the Department of Foreign Affairs said that St Patrick’s Day is "an unparalleled opportunity to promote Ireland as a great place to visit, work, study, trade with, and invest in".
"The theme for St Patrick’s Day 2024 will be 'Ireland’s Future in the World', which will focus on young Irish people, and our diaspora, and their perspectives about the world of the future and Ireland’s place in it. It will highlight the impact and achievements of young Irish and diaspora leaders across the fields of innovation, creativity, community development, business, and academia around the world.
"Ministers will emphasise Ireland’s commitment to international peace and security and the rules-based multilateral system, especially at this time of conflict and turbulence. Other key messages will include the strength of Ireland’s economy, our active membership of the European Union, our commitment to protecting the Good Friday Agreement, and the high priority we attach to climate action and sustainability."