The final links to open are on the N25 westbound and from Little Island to the M8 northbound, with Tánaiste Micheál Martin due to conduct an official opening of the overall project.
Completion of the main construction works will be followed by a three-year maintenance period during which the operation of the interchange will be monitored.
Work on the complex engineering project has been likened to performing open heart surgery on a patient — while they are awake.
A total of 18 new road links have been built over 10km, while the amount of new pavement laid down is 150,000 sqm, which is about two-and-a-half times as big as Croke Park.
The million cubic metres of earthworks moved would be enough to fill 400 Olympic-sized swimming pools while the total 22,500m length of drainage pipes installed is about two-and-a-half times as tall as Mount Everest.
A night-time working blitz in recent weeks got the project to its completion milestone on Monday.
The interchange the junction of four national roads, the M8 Cork - Dublin Motorway, the N25 Cork - Waterford / Rosslare route, the N40 Cork South Ring Road and the N8 Dunkettle - Cork city National Route
Around 120,000 vehicles pass through the interchange on the busier days of the week.