Former British prime ministers Boris Johnson and Liz Truss are expected to vote against Rishi Sunak’s Brexit deal.
Mr Johnson, who had already voiced concerns about the deal brokered with Brussels, confirmed that he will not be backing the deal when MPs vote on the Stormont brake in the House of Commons later on Wednesday.
In a statement, Mr Johnson said: “The proposed arrangements would mean either that Northern Ireland remained captured by the EU legal order – and was increasingly divergent from the rest of the UK – or they would mean that the whole of the UK was unable properly to diverge and take advantage of Brexit.
“That is not acceptable. I will be voting against the proposed arrangements today.
“Instead, the best course of action is to proceed with the Northern Ireland Protocol Bill, and make sure that we take back control.”
With Labour backing the Windsor Framework agreement signed last month, the British government should win the Commons division comfortably, despite criticism from some hardline Tory Brexiteers.
The DUP has already said its eight MPs will vote against the regulation to implement the Stormont brake as it continues to seek changes to the overall framework.
A source close to Ms Truss said she also plans to vote against the post-Brexit deal for Northern Ireland. She is understood to believe that it does not “satisfactorily resolve the issues thrown up by” the Northern Ireland Protocol and “almost fatally impinges” on the UK’s ability to diverge from EU rules and regulations.
The confirmation by Mr Johnson of his opposition to the UK-EU deal comes ahead of his appearance before the Privileges Committee, where he will be grilled by MPs investigating claims he knowingly misled the UK parliament over the “partygate” affair.
Mr Johnson, who agreed the original Northern Ireland Protocol with Brussels as a way to avoid a hard border on the island of Ireland, had earlier this month indicated that he would find it “very difficult” to support the Windsor agreement.
It remains to be seen how large a rebellion Mr Sunak will face, when the secondary legislation on the Stormont brake comes before MPs.
On Tuesday the European Research Group (ERG) said the brake, which is intended to provide a veto on the imposition of new EU regulations in Northern Ireland, was “practically useless” following an analysis of the framework by its “star chamber” of lawyers.
Eurosceptic members have not yet decided how to vote, with the group set to meet later on Wednesday.
British foreign secretary James Cleverly is due to meet the EU’s Maros Sefcovic in London on Friday to formally adopt the Windsor pact at a meeting of the joint committee on the Withdrawal Agreement.
While the DUP is not in a position to block it, their opposition suggests that an early return to powersharing at Stormont is highly unlikely.
The executive and assembly have been suspended since the DUP walked out last year in protest at the way the protocol was operating, saying it weakened Northern Ireland’s position in the UK.
Downing Street has indicated that there could be further votes in the weeks ahead on the statutory instruments needed to implement other elements of the framework.
However, there is frustration among some MPs that Mr Sunak is resisting calls for an overall vote on the whole framework document.